The leak was also reversed within days of stopping the medication. The manifestations of drug induced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. Start studying therapy drug induced hematologic disorders. Aplastic anemia occurs when the bone marrow fails and production of red blood cells, white cells, and platelets ceases i. Drug induced thrombocytopenia is the most common druginduced hematologic disorders, with some reports suggesting that as many as 5% of patients who receive heparin develop heparin induced thrombocytopenia. These reactions are the most common adrs involving the skin. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet. The manifestations of druginduced pulmonary diseases span the entire spectrum of pathophysiologic conditions of the respiratory tract. Megaloblastic, aplastic and hemolytic anemias are the most common drug induced anemias. Full text full text is available as a scanned copy of the original print version.
Druginduced blood disorders more common in elderly risk of death increases with age agranulcytosis risk higher in women and those 60 yo. The neutropenia and thrombocytopenia resolved after discontinuation of phenobarbital 8 days and 15 days after discontinuation, respectively. Druginduced kidney disease pathology and current concepts. Get a printable copy pdf file of the complete article 152k. Drug induced aplastic anemia accounts for 7% to 86% of total cases of aplastic anemia. Drug induced renal disease, like other iatrogenic disorders, bedevils the patient and humbles the physician when he finds that he has done harm at the time he thought he was doing good. Markowitz and others were the first to report the association between pamidronate and collapsing glomerulopathy. Druginduced liver injury dili accounts for aug, 2014 drug induced bleeding disorders 1. Pdf file of the complete article 152k, or click on a page image below to browse page by page. Drug induced hematologic disorders is a topic covered in the pocket icu management to view the entire topic, please sign in or purchase a subscription anesthesia central is an allinone web and mobile solution for treating patients before, during, and after surgery. Sign in with your ashp username and password to access purchased ebooks in my library. It is common in older adults, and increasing age is associated with a marked increase in the incidence of.
The four major blood dyscrasias attributable to drugs are. The book is divided into eight chapters, the first three dealing with general aspects of drug reactions and principles of diagnosis, reporting and prevention, and the last five dealing with specific drug reactions. Druginduced blood dyscrasias require prompt action. This is the first case report in korea to demonstrate blood dyscrasia associated. Agranulocytosis or leukopenia loss of the white blood cells aplastic anemia loss of all the formed elements of the blood thrombocytopenia loss of the platelets hemolytic. Identify risk factors for high probability did causation. A casehistory study of druginduced blood disorders pancytopenia, hemolytic anemia, thrombocytopenia, and granulocytopenia was carried out at the group health cooperative of puget sound, a health maintenance organization with more than 200,000 members, for the tenyear period from 1972 through 1981. Therapy drug induced hematologic disorders quizlet. Drugs considered lupus inducing vary in pharmacologic.
Additionally, advice is offered on how physicians might distinguish drug induced cardiovascular disorders from other aetiologies. Druginduced hematologic syndromes article pdf available in advances in hematology 20096. Drugs can produce toxicity through three major mechanisms. Sep 23, 2010 to address this common clinical problem, we used 3 distinct analytical methods and their corresponding datasets to identify drugs that have evidence for an association with thrombocytopenia. Some authors have reported a peak incidence in patients younger than 30 years of age, although others report the. Get a printable copy pdf file of the complete article 152k, or click on a page image below to browse page by page. If your doctor thinks you may be having a reaction to a drug, he or she may ask you to stop taking the medication. This thickened more viscous blood may have difficulty passing through small blood vessels, decreasing blood flow to certain areas of the body, which is a serious condition called hyperviscosity. History of broken relationships, alcoholism or drug addiction and school or social pressures.
If that happens, you have drug induced thrombocytopenia. Agranulocytosis or leukopenia loss of the white blood cells aplastic anemia loss of all the formed elements of the blood thrombocytopenia loss of the platelets hemolytic anemia loss of the red blood. Druginduced hematologic disorders pocket icu management. Jan 17, 2020 additional blood tests will be ordered at the same time to help diagnose why you have thrombocytopenia. Menstrual disorders reproductive age in the reproductive age, psychologic causes of menstrual disorers involve marital and sex life, a detailed history might reveal significant events that precedes anovulatory episodes. As with most drug induced diseases, the pathological changes are nonspecifi c. The first page of the pdf of this article appears above. Druginduced hematologic disorders is a topic covered in the pocket icu management to view the entire topic, please sign in or purchase a subscription anesthesia central is an allinone web and mobile solution for treating patients before, during, and after surgery. Identify the laboratory tests required to rule inout as drug induced causation. Blood disorders affect one or more parts of the blood and prevent your blood from doing its job.
Specific attention is given to certain drug groups with a strong association with one or more forms of cardiovascular disease. Drug induced pseudorenal failure bun due to protein catabolism steroids, tetracyclines scr due to competitive inhibition of creatinine secretion trimethoprim, cimetidine, triamterene with trimethoprim 1535% rise scr fully expressed after 3 days more sig in pts with preexisting renal dysfunction can occur with normal doses completely. Traumainduced coagulopathy together with hemodilution due to massive transfusion of red blood cells and ffps 35 is a common cause of thrombocytopenia in the icu. These drugs cause an autoimmune response the body attacks its own cells producing symptoms similar to those of sle. A casehistory study of drug induced blood disorders pancytopenia, hemolytic anemia, thrombocytopenia, and granulocytopenia was carried out at the group health cooperative of puget sound, a health maintenance organization with more than 200,000 members, for the tenyear period from 1972 through. From there, you can view and download your ashp ebooks to the reader of your choice. As the variety and range of pharmaceutical agents available to the medical profession continues to expand, one unavoidable effect will be an increase in druginduced disease, including cardiovascular disorders. Signs and symptoms of druginduced lupus erythematosus include the following. Proceedings of the royal society of medicine, 01 apr 1976, 694. These tend to be relatively common, are always serious, and frequently can be lifethreatening. Drug induced blood disorders have also been the reason for withdrawal for a number of drugs, notably remoxipride in 1994. Learn vocabulary, terms, and more with flashcards, games, and other study tools.
This rare adverse effect occurs in approximately 15,000 to 30,000 individuals per year in the united states. Drug induced hematological disorders barbra doziers blog. Druginduced kidney diseasealwin hl loh and arthur h cohen cellular, tip and collapsing. Identifying drugs that cause acute thrombocytopenia. Druginduced blood disorders europe pmc article europe. Approximately 163,000 older americans suffer from serious mental impairment memory loss, dementia either caused or worsened by drugs. Drug induced hematology lecturer nin prapongsena huachiew chalermprakiet university 2. Drugs can affect all types of blood cells and induce different disorders. Blood disorders, many of which carry an attendant high morbidity or mortality, constitute a significant part of druginduced problems. Druginduced liver injury dili accounts for drug induced hematologic disorders.
Drug induced hematologic disorders can affect any cell line, including white blood cells wbcs, red blood cells rbcs, and platelets. Identify the components of the history required to rule inout a drug causation. It is not uncommon for patients with ditp to be initially diagnosed as having autoimmune. Get a printable copy pdf file of the complete article 223k, or click on a page image below to browse page by page. Dosage adjustments are often required based on patient age, renal and hepatic function, etc. Acute immunemediated thrombocytopenia is a potentially serious adverse reaction to many drugs. Scale underutilized for determining probability of adverse drug events. Apr 23, 2012 chronic disorders include drug induced lupus, drug induced acne, and pigmentary changes. The man is forced into a gown, to prevent harm to himself. Physiological deficiencies the coagulation system of the newborn infant is complex and reflects hepatic immaturity. Druginduced hematologic disorders can affect any cell line, including white blood cells wbcs, red blood cells rbcs, and platelets. The er nurse comes in and asks to draw blood from the patient. Apr 01, 2010 scale underutilized for determining probability of adverse drug events. Druginduced pulmonary disease due to nonchemotherapeutic.
However, given the high rates of cardiovascular disease and prevalence of recognised cardiovascular risk factors in the population, it is. Weiss, md, college of medicine, university of arizona hypokalemia is one of the most common electrolyte disorders seen in both outpatient practice and inpatient care. Drug induced anemias are potentially dangerous and have long been a risk of modern pharmacotherapy. One price of the therapeutic revolution is the everincreasing number of adverse drug reactions.
Review article druginduced megaloblastic, aplastic, and. Renal disease induced by drugs was studied by percutaneous biopsy in 40 patients. Identify an approach to incorporating did wi the differential. Trauma induced coagulopathy together with hemodilution due to massive transfusion of red blood cells and ffps 35 is a common cause of thrombocytopenia in the icu. The mechanisms of drug induced anemia can be explained. When a drug causes decreases in all three cell lines accompanied by a hypoplastic bone marrow, the result is drug induced aplastic anemia. Therefore, the diagnosis is often diffi cult and, in most cases, is based on exclusion of all other possible causes. Druginduced renal disease, like other iatrogenic disorders, bedevils the patient and humbles the physician when he finds that he has done harm at the time he thought he was doing good. Acute posthemorrhagic anemia anemia in neoplastic disease anemia in chronic kidney disease anemia in other chronic disease. Symptoms of blood disorders merck manuals consumer version. Druginduced diseases focus of pharmacy manual managed care. When a drug causes decreases in all three cell lines accompanied by a hypoplastic bone marrow, the result is druginduced aplastic anemia. Antipsychotic medication reference user guide usual dosage ranges represent treatment of schizophrenia in healthy adults unless otherwise indicated. Nov 19, 20 this drug induced hematological disorders span the whole range of body hematology affecting red blood cells, platelets, coagulation system, and the white blood cells.
The nurse restrains the patient and draws the blood illegally. Blood disorders, many of which carry an attendant high morbidity or mortality, constitute a significant part of drug induced problems. Recognition and management of druginduced blood disorders. Zidovudine still first choice in hiv treatment but early use is questioned. Drug induced lupus erythematosus is an autoimmune disorder similar to systemic lupus erythematosus sle caused by chronic use of certain drugs. Some blood disorders cause a persons blood to become thickened by increased quantities of immunerelated proteins, red blood cells, or platelets. The doctor will then see if your platelet count rises. Druginduced diseases focus of pharmacy manual managed. Esomeprazole induced a significant transmucosal leak in the upper gi tract of patients taking the drug for the first time. How i evaluate and treat thrombocytopenia in the intensive. As with most druginduced diseases, the pathological changes are nonspecifi c. The leak occurred quickly, within days of first taking the drug. After ruling out other possible causes of cytopenias, a tentative diagnosis was made of druginduced blood cell dyscrasia. Blood disorders united states pdf ppt case reports.
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